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Below is a summary assembled by the Research & Innovation Office (RIO).Please see the full solicitation for complete information about the funding opportunity.ÌýÌýÌý

Program SummaryÌý

This Notice of Funding Opportunity (NOFO) solicits applications to develop shared-use research facilities or research-supporting facilities that enable collaborative research and benefit broad research communities at large. The NOFO supports two existing construction programs: the Biomedical Research Facilities (BRF) program and the HIV/AIDS Research Facilities (HRF) program.

The BRF program supports the construction or modernization of biomedical research facilities that advance basic, translational, clinical, or behavioral science research in all areas. Intended facilities include shared research spaces, core facilities, biorepositories, or other shared-use resource facilities that serve a broad scientific community with a significant, long-term impact on biomedical research.

The HRF program funds the development of HIV/AIDS research or research-supporting resources that the empowered research activities must align with the NIH Office of AIDS Research (OAR) priorities, as outlined at , including research focusing on the long-term health consequences of HIV infection.

NIH encourages applications from institutions across all geographic regions of the country, including Institutions of Emerging Excellence (IEE) in biomedical research, to strengthen the nation’s research capacity.

The project should meet the following criteria and documentation requirements:

• The project must be essential for biomedical research activities supported and the space involved will be used for these activities.
• The facility must be utilized for the biomedical research purposes for which it was constructed or improved for at least 10 years beginning on the date of beneficial occupancy of the space.
• For modernization and renovation projects, the structure must be architecturally and physically suitable for conversion to the type of research space required.
• If the space is rented, evidence must be provided that the terms of the lease and expected subsequent use of the facility are consistent with the proposed project. Specifically, a signed document from the building owner must be provided, detailing that the terms of the lease agreement and subsequent use of the facility will comply with the 10-year term of the Notice of Federal Interest (NFI) requirement following the occupancy of the facility. A statement of agreement by the owner of the space must be included at the time of application submission. These documents will be verified if/when the application is considered for funding.
• If the project affects a site listed (or eligible for inclusion) in the National Register of Historic Places, the requirements specified in "Preservation of Cultural and Historic 91´«Ã½" must be followed.

Deadlines

• CU Internal Deadline: 11:59pm MT March 22, 2026
• Sponsor Application Deadline: April 6, 2026

Internal Application Requirements (all in PDF format)

• Scientific Justification and Facility Development (2 pages maximum): Justify the request from a scientific perspective and describe the technical design approaches with enough details to make clear the merits of the overall project, including plans for long-term use of the space by many researchers. The Scientific Justification should explain how the project expands biomedical research capabilities and addresses infrastructure needs, while the Development of the Facility should present technical specifications, architectural and engineering design, and proposed construction processes.Ìý
• PI Curriculum Vitae
• Budget Overview (1 page maximum): A basic budget outlining project costs is sufficient; detailed OCG budgets are not required.

To access the online application, visit:

Eligibility

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed construction as the Program Director/Principal Investigator (PD/PI) is invited to work with their organization to develop an application for support. Multiple PDs/PIs are not allowed.

The PD/PI should hold appropriate stature within the institutional administration structure and research community to be able to oversee various facets of the entire project. The PD/PI should also have a demonstrated record of leadership skills to recruit and guide expert Key Personnel with complementary technical and scientific skills to successfully accomplish the construction project.

Limited Submission Guidelines

Only one application per institution (identified by NIH IPF number) is allowed.

Award Information and Duration

The allowed direct cost (Total Federal Funds Requested) is $2,000,000 to $8,000,000 for BRF facilities and $2,000,000 to $4,000,000 for HRF facilities. Applications with a budget less than $2,000,000 will not be considered.

Award Term: Up to 5 years

Review Criteria

Please consider NIH’s specific reviewÌý as the proposal is developed. The internal review committee will use these criteria as a guide when evaluating internal proposals.Ìý